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Les biomarqueurs du liquide cérébro-spinal dans la maladie d’Alzheimer : un outil de recherche utile dans la pratique clinique courante des consultations mémoire pour les cas complexes

Abstract : The role of biomarkers in clinical research was recently highlighted in the new criteria for the diagnosis of Alzheimer's disease. Cerebro-spinal fluid (CSF) biomarkers (total Tau protein, threonine 181 phosphorylated Tau protein and amyloid Aβ1-42 peptide) are associated with cerebral neuropathological lesions observed in Alzheimer's disease (neuronal death, neurofibrillary tangle with abnormal Tau deposits and amyloid plaque). Aβ1-40 amyloid peptide dosage helps to interpret Aβ1-42 results. As suggested in the latest international criteria and the French HAS (Haute Autorité de santé) recommendations, using theses CSF biomarkers should not be systematic but sometimes could be performed to improve confidence about the diagnostic of Alzheimer's disease in young subjects or in complex clinical situations. Future biomarkers actually in development will additionally help in diagnostic process (differential diagnosis) and in prognostic evaluation of neurodegenerative diseases.
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https://hal-univ-fcomte.archives-ouvertes.fr/hal-03630199
Contributor : Eloi Magnin Connect in order to contact the contributor
Submitted on : Monday, April 4, 2022 - 6:51:14 PM
Last modification on : Monday, April 4, 2022 - 6:51:15 PM

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E. Magnin, J. Dumurgier, E. Bouaziz-Amar, S. Bombois, D. Wallon, et al.. Les biomarqueurs du liquide cérébro-spinal dans la maladie d’Alzheimer : un outil de recherche utile dans la pratique clinique courante des consultations mémoire pour les cas complexes. La Revue De Médecine Interne, Elsevier, 2017, 38 (4), pp.250-255. ⟨10.1016/j.revmed.2016.10.383⟩. ⟨hal-03630199⟩

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