Semantic loss marks early Alzheimer's disease‐related neurodegeneration in older adults without dementia

Jet Vonk , Vincent Bouteloup , Jean-François Mangin , Bruno Dubois , Frédéric Blanc , Audrey Gabelle , Mathieu Ceccaldi , Cédric Annweiler , Pierre Krolak-Salmon , Catherine Belin , Thérèse Rivasseau-Jonveaux , Adrien Julian , François Sellal , Eloi Magnin (1) , Marie Chupin , Marie-Odile Habert , Geneviève Chêne , Carole Dufouil , Jean‐françois Mangin , Pierre Krolak‐salmon , Thérèse Rivasseau‐jonveaux , Marie‐odile Habert

1 UFC - Université de Franche-Comté

To assess progression of semantic loss in early stages of cognitive decline using semantic and letter fluency performance, and its relation with Alzheimer's disease (AD)-specific neurodegeneration using longitudinal multimodal neuroimaging measures.

Keywords: Alzheimer's disease; MCI; amnestic; biomarkers; category fluency; cognitive aging; cohort studies; letter fluency; neuroimaging; semantic fluency; verbal fluency

Domains: Life Sciences [q-bio]

Jet Vonk, Vincent Bouteloup, Jean-François Mangin, Bruno Dubois, Frédéric Blanc, et al.. Semantic loss marks early Alzheimer's disease‐related neurodegeneration in older adults without dementia. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 2020, 12 (1), pp.e12066. ⟨10.1002/dad2.12066⟩. ⟨hal-03630133⟩