HAL will be down for maintenance from Friday, June 10 at 4pm through Monday, June 13 at 9am. More information
Skip to Main content Skip to Navigation
Journal articles

Transcranial direct current stimulation (tDCS) reduces motivation to drink ethanol and reacquisition of ethanol self-administration in female mice

Abstract : Abstract Transcranial direct current stimulation (tDCS) is an emerging noninvasive brain neuromodulation technique aimed at relieving symptoms associated with psychiatric disorders, including addiction. The goal of the present study was to better identify which phase of alcohol-related behavior (hedonic effect, behavioral sensitization, self-administration, or motivation to obtain the drug) might be modulated by repeated anodal tDCS over the frontal cortex (0.2 mA, 20 min, twice a day for 5 consecutive days), using female mice as a model. Our data showed that tDCS did not modulate the hedonic effects of ethanol as assessed by a conditioned place preference test (CPP) or the expression of ethanol-induced behavioral sensitization. Interestingly, tDCS robustly reduced reacquisition of ethanol consumption (50% decrease) following extinction of self-administration in an operant paradigm. Furthermore, tDCS significantly decreased motivation to drink ethanol on a progressive ratio schedule (30% decrease). Taken together, our results show a dissociation between the effects of tDCS on “liking” (hedonic aspect; no effect in the CPP) and “wanting” (motivation; decreased consumption on a progressive ratio schedule). Our tDCS procedure in rodents will allow us to better understand its mechanisms of action in order to accelerate its use as a complementary and innovative tool to help alcohol-dependent patients maintain abstinence or reduce ethanol intake.
Document type :
Journal articles
Complete list of metadata

https://hal-univ-fcomte.archives-ouvertes.fr/hal-03630104
Contributor : Emmanuel Haffen Connect in order to contact the contributor
Submitted on : Monday, April 4, 2022 - 5:46:52 PM
Last modification on : Tuesday, April 5, 2022 - 10:05:53 AM

Links full text

Identifiers

Collections

Citation

Solène Pedron, Stéphanie Dumontoy, Maria del Carmen González-Marín, Fabien Coune, Andries van Schuerbeek, et al.. Transcranial direct current stimulation (tDCS) reduces motivation to drink ethanol and reacquisition of ethanol self-administration in female mice. Scientific Reports, Nature Publishing Group, 2022, 12 (1), pp.198. ⟨10.1038/s41598-021-03940-2⟩. ⟨hal-03630104⟩

Share

Metrics

Record views

27