Transcranial direct current stimulation (tDCS) reduces motivation to drink ethanol and reacquisition of ethanol self-administration in female mice - Archive ouverte HAL Access content directly
Journal Articles Scientific Reports Year : 2022

Transcranial direct current stimulation (tDCS) reduces motivation to drink ethanol and reacquisition of ethanol self-administration in female mice

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Solène Pedron
  • Function : Author
Stéphanie Dumontoy
  • Function : Author
Maria del Carmen González-Marín
  • Function : Author
  • PersonId : 1151751
  • IdRef : 167037021
Fabien Coune
  • Function : Author
  • PersonId : 1151710
  • IdRef : 195933826
Andries van Schuerbeek
  • Function : Author
Emmanuel Haffen
Mickael Naassila

Abstract

Abstract Transcranial direct current stimulation (tDCS) is an emerging noninvasive brain neuromodulation technique aimed at relieving symptoms associated with psychiatric disorders, including addiction. The goal of the present study was to better identify which phase of alcohol-related behavior (hedonic effect, behavioral sensitization, self-administration, or motivation to obtain the drug) might be modulated by repeated anodal tDCS over the frontal cortex (0.2 mA, 20 min, twice a day for 5 consecutive days), using female mice as a model. Our data showed that tDCS did not modulate the hedonic effects of ethanol as assessed by a conditioned place preference test (CPP) or the expression of ethanol-induced behavioral sensitization. Interestingly, tDCS robustly reduced reacquisition of ethanol consumption (50% decrease) following extinction of self-administration in an operant paradigm. Furthermore, tDCS significantly decreased motivation to drink ethanol on a progressive ratio schedule (30% decrease). Taken together, our results show a dissociation between the effects of tDCS on “liking” (hedonic aspect; no effect in the CPP) and “wanting” (motivation; decreased consumption on a progressive ratio schedule). Our tDCS procedure in rodents will allow us to better understand its mechanisms of action in order to accelerate its use as a complementary and innovative tool to help alcohol-dependent patients maintain abstinence or reduce ethanol intake.

Dates and versions

hal-03596792 , version 1 (03-03-2022)

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Solène Pedron, Stéphanie Dumontoy, Maria del Carmen González-Marín, Fabien Coune, Andries van Schuerbeek, et al.. Transcranial direct current stimulation (tDCS) reduces motivation to drink ethanol and reacquisition of ethanol self-administration in female mice. Scientific Reports, 2022, 12 (1), pp.198. ⟨10.1038/s41598-021-03940-2⟩. ⟨hal-03596792⟩

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