Longitudinal study assessing the return of chloroquine susceptibility of Plasmodium falciparum in isolates from travellers returning from West and Central Africa, 2000–2011

Dima El Safadi , Amandine Cian , Céline Nourrisson , Bruno Pereira , Christelle Morelle , Patrick Bastien , Anne-Pauline Bellanger (1, 2) , Françoise Botterel , Ermanno Candolfi , Guillaume Desoubeaux , Laurence Lachaud , Florent Morio , Christelle Pomares , Meja Rabodonirina , Ivan Wawrzyniak , Frédéric Delbac , Nausicaa Gantois , Gabriela Certad , Laurence Delhaes , Philippe Poirier , Eric Viscogliosi , Myriam Gharbi , Jennifer Flegg , Véronique Hubert , Eric Kendjo , Jessica Metcalf , Lionel Bertaux , Philippe Guérin , Jacques Le Bras , Ahmed Aboubaca , Patrice Agnamey , Adela Angoulvant , Patricia Barbut , Didier Basset , Ghania Belkadi , Anne Pauline Bellanger , Dieudonné Bemba , Françoise Benoit-Vica , Antoine Berry , Marie-Laure Bigel , Julie Bonhomme , Olivier Bouchaud , Marie-Elisabeth Bougnoux , Patrice Bourée , Nathalie Bourgeois , Catherine Branger , Laurent Bret , Bernadette Buret , Enrique Casalino , Sylviane Chevrier , Frédérique Conquere de Monbrison , Bernadette Cuisenier , Martin Danis , Marie-Laure Darde , Ludovic de Gentile , Jean-Marie Delarbre , Pascal Delaunay , Anne Delaval , Michel Develoux , Jean Dunand , Rémy Durand , Odile Eloy , Nathalie Fauchet , Bernard Faugere , Alber Faye , Odile Fenneteau , Pierre Flori , Madeleine Fontrouge , Chantal Garabedian , Françoise Gayandrieu , Nadine Godineau , Pascal Houzé , Sandrine Houzé , Jean-Pierre Hurst , Houria Ichou , Agathe Lebuisson , Magalie Lefevre , Anne-Sophie Leguern , Gwenaë Le Moal , Daniel Lusina , Marie-Claude Machouart , Denis Malvy , Sophie Matheron , Danièle Maubon , Denis Mechali , Bruno Megarbane , Guillaume Menard , Laurence Millon , Muriel Mimoun Aiach , Philippe Minodier , Gilles Nevez , Philippe Parola , Daniel Parzy , Olivier Patey , Pierre Patoz , Pascale Penn , Alice Perignon , Stéphane Picot , Jean-Etienne Pilo , Isabelle Poilane , Denis Pons , Marie Poupart , Bruno Pradines , Didier Raffenot , Christophe Rapp , Marie-Catherine Receveur , Claudine Sarfati , Yaye Senghor , Fabrice Simon , Jean-Yves Siriez , Nicolas Taudon , Marc Thellier , Maxime Thouvenin , Dominique Toubas

1 Service de parasitologie et mycologie [CHRU de Besançon]
2 LCE - Laboratoire Chrono-environnement (UMR 6249)

Chloroquine (CQ) was the main malaria therapy worldwide from the 1940s until the 1990s. Following the emergence of CQ-resistant Plasmodium falciparum, most African countries discontinued the use of CQ, and now promote artemisinin-based combination therapy as the first-line treatment. This change was generally initiated during the last decade in West and Central Africa. The aim of this study is to describe the changes in CQ susceptibility in this African region, using travellers returning from this region as a sentinel system.

Keywords: Blastocystis sp; Intestinal parasite; Molecular epidemiology; PCR; Risk factors for infection; Subtyping

Domains: Life Sciences [q-bio]; Ecology, environment; Health

Dima El Safadi, Amandine Cian, Céline Nourrisson, Bruno Pereira, Christelle Morelle, et al.. Longitudinal study assessing the return of chloroquine susceptibility of Plasmodium falciparum in isolates from travellers returning from West and Central Africa, 2000–2011. Malaria Journal, 2013, 12 (1), pp.35. ⟨10.1186/1475-2875-12-35⟩. ⟨hal-03528300⟩