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Journal articles

A Standard Numbering Scheme for Class C β-Lactamases

Abstract : Unlike for classes A and B, a standardized amino acid numbering scheme has not been proposed for the class C (AmpC) β-lactamases, which complicates communication in the field. Here, we propose a scheme developed through a collaborative approach that considers both sequence and structure, preserves traditional numbering of catalytically important residues (Ser 64 , Lys 67 , Tyr 150 , and Lys 315 ), is adaptable to new variants or enzymes yet to be discovered and includes a variation for genetic and epidemiological applications.
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Contributor : Isabelle HOSTALIER Connect in order to contact the contributor
Submitted on : Thursday, December 16, 2021 - 11:45:14 AM
Last modification on : Sunday, June 26, 2022 - 3:25:50 AM

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Andrew Mack, Melissa Barnes, Magdalena Taracila, Andrea Hujer, Kristine Hujer, et al.. A Standard Numbering Scheme for Class C β-Lactamases. Antimicrobial Agents and Chemotherapy, American Society for Microbiology, 2020, 64 (3), ⟨10.1128/AAC.01841-19⟩. ⟨hal-03482894⟩



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