Unlike for classes A and B, a standardized amino acid numbering scheme has not been proposed for the class C (AmpC) β-lactamases, which complicates communication in the field. Here, we propose a scheme developed through a collaborative approach that considers both sequence and structure, preserves traditional numbering of catalytically important residues (Ser 64 , Lys 67 , Tyr 150 , and Lys 315 ), is adaptable to new variants or enzymes yet to be discovered and includes a variation for genetic and epidemiological applications.
Andrew Mack, Melissa Barnes, Magdalena Taracila, Andrea Hujer, Kristine Hujer, et al.. A Standard Numbering Scheme for Class C β-Lactamases. Antimicrobial Agents and Chemotherapy, 2020, 64 (3), ⟨10.1128/AAC.01841-19⟩. ⟨hal-03482894⟩