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Journal Articles Antimicrobial Agents and Chemotherapy Year : 2020

A Standard Numbering Scheme for Class C β-Lactamases

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Andrew Mack
Melissa Barnes
  • Function : Author
Magdalena Taracila
  • Function : Author
Andrea Hujer
  • Function : Author
Kristine Hujer
  • Function : Author
Gabriel Cabot
Michael Feldgarden
  • Function : Author
Daniel Haft
  • Function : Author
William Klimke
  • Function : Author
Focco van den Akker
  • Function : Author
Alejandro Vila
  • Function : Author
Andrea Smania
  • Function : Author
Shozeb Haider
  • Function : Author
Krisztina Papp-Wallace
Patricia Bradford
Gian Maria Rossolini
  • Function : Author
Jean-Denis Docquier
  • Function : Author
Jean-Marie Frère
  • Function : Author
Moreno Galleni
  • Function : Author
Nancy Hanson
  • Function : Author
Antonio Oliver
Laurent Poirel
  • Function : Author
Patrice Nordmann
  • Function : Author
Timothy Palzkill
George Jacoby
  • Function : Author
Karen Bush
Robert Bonomo
  • Function : Author

Abstract

Unlike for classes A and B, a standardized amino acid numbering scheme has not been proposed for the class C (AmpC) β-lactamases, which complicates communication in the field. Here, we propose a scheme developed through a collaborative approach that considers both sequence and structure, preserves traditional numbering of catalytically important residues (Ser 64 , Lys 67 , Tyr 150 , and Lys 315 ), is adaptable to new variants or enzymes yet to be discovered and includes a variation for genetic and epidemiological applications.

Dates and versions

hal-03482894 , version 1 (16-12-2021)

Identifiers

Cite

Andrew Mack, Melissa Barnes, Magdalena Taracila, Andrea Hujer, Kristine Hujer, et al.. A Standard Numbering Scheme for Class C β-Lactamases. Antimicrobial Agents and Chemotherapy, 2020, 64 (3), ⟨10.1128/AAC.01841-19⟩. ⟨hal-03482894⟩
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