Arboviral Risk Associated with Solid Organ and Hematopoietic Stem Cell Grafts: The Prophylactic Answers Proposed by the French High Council of Public Health in a National Context

Bruno Pozzetto (1, 2) , Gilda Grard , Guillaume Durand , Marie-Claire Paty , Pierre Gallian (3, 4) , Sophie Lucas-Samuel , Stéphanie Diéterlé , Muriel Fromage , Marc Durand , Didier Lepelletier , Christian Chidiac , Bruno Hoen , Xavier Nicolas de Lamballerie

1 HCSP - Haut Conseil de la Santé Publique
2 GIMAP - Physiopathologie et biothérapies des infections muqueuses
3 UVE - Unité des Virus Emergents
4 EFS - Etablissement Français du Sang [La Plaine Saint-Denis]

Diseases caused by arboviruses are on the increase worldwide. In addition to arthropod bites, most arboviruses can be transmitted via accessory routes. Products of human origin (labile blood products, solid organs, hematopoietic stem cells, tissues) present a risk of contamination for the recipient if the donation is made when the donor is viremic. Mainland France and its overseas territories are exposed to a complex array of imported and endemic arboviruses, which differ according to their respective location. This narrative review describes the risks of acquiring certain arboviral diseases from human products, mainly solid organs and hematopoietic stem cells, in the French context. The main risks considered in this study are infections by West Nile virus, dengue virus, and tick-borne encephalitis virus. The ancillary risks represented by Usutu virus infection, chikungunya, and Zika are also addressed more briefly. For each disease, the guidelines issued by the French High Council of Public Health, which is responsible for mitigating the risks associated with products of human origin and for supporting public health policy decisions, are briefly outlined. This review highlights the need for a “One Health” approach and to standardize recommendations at the international level in areas with the same viral epidemiology.

Mots clés: products of human origin; solid organ; hematopoietic stem cell; West Nile virus; dengue virus; tick-borne encephalitis virus; Usutu virus; chikungunya virus; Zika virus; France

Domaines: Sciences du Vivant [q-bio]

Bruno Pozzetto, Gilda Grard, Guillaume Durand, Marie-Claire Paty, Pierre Gallian, et al.. Arboviral Risk Associated with Solid Organ and Hematopoietic Stem Cell Grafts: The Prophylactic Answers Proposed by the French High Council of Public Health in a National Context. Viruses, 2023, 15 (9), pp.1783. ⟨10.3390/v15091783⟩. ⟨hal-04225662⟩