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Effects of smoking status and MADRS retardation factor on response to low frequency repetitive transcranial magnetic stimulation for depression

Abstract : Abstract Background Despite growing evidence supporting the clinical interest of repetitive transcranial magnetic stimulation (rTMS) in treatment-resistant depression (TRD), little is known regarding the effects of clinical and sociodemographic factors on the clinical outcome in patients. Methods We retrospectively investigated the effects of clinical (using the 3-factor model of the Montgomery-Åsberg depression rating scale [MADRS] encompassing dysphoria, retardation and vegetative symptoms) and sociodemographic characteristics of participants on clinical outcome in a sample of 54 TRD patients receiving low frequency rTMS (1 Hz, 360 pulses) applied over the right dorsolateral prefrontal cortex combined with sham venlafaxine. Results Responders ( n = 29) displayed lower retardation baseline scores (13.6 ± 2.9) than non-responders (15.6 ± 2.9; n = 25; P = 0.02). We also observed a significant difference between the numbers of ex-smokers in responders and non-responders groups; all ex-smokers ( n = 8) were responders to rTMS ( P = 0.005). Conclusion Low MADRS retardation factor and ex-smoker status is highly prevalent in responders to low frequency rTMS. Further studies are needed to investigate the predictive value of these factors.
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https://hal-univ-fcomte.archives-ouvertes.fr/hal-03658166
Contributor : Emmanuel Haffen Connect in order to contact the contributor
Submitted on : Tuesday, May 3, 2022 - 4:06:11 PM
Last modification on : Wednesday, May 4, 2022 - 3:45:51 AM

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E. Poulet, F. Galvao, E. Haffen, D. Szekely, C. Brault, et al.. Effects of smoking status and MADRS retardation factor on response to low frequency repetitive transcranial magnetic stimulation for depression. European Psychiatry, Cambridge University press, 2016, 38, pp.40-44. ⟨10.1016/j.eurpsy.2016.04.004⟩. ⟨hal-03658166⟩

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