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Article Dans Une Revue Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring Année : 2018

Plasma amyloid levels within the Alzheimer's process and correlations with central biomarkers

1 Centre de Mémoire de Ressources et de Recherche [Paris Broca]
2 EA 4468 - Maladie d'Alzheimer : marqueurs génétiques et vasculaires, neuropsychologies
3 Cellules Souches, Plasticité Cellulaire, Médecine Régénératrice et Immunothérapies (IRMB)
4 TCDV - Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046
5 U894 - Centre de Psychiatrie et Neurosciences
6 Hôpital Necker - Enfants Malades [AP-HP]
7 LilNCog - Lille Neurosciences & Cognition - U 1172
8 Centre Mémoire de Ressources et de Recherche [Hôpitaux Civils de Colmar, Strasbourg]
9 CATI - Centre d'Acquisition et de Traitement des Images [Paris] = CATI Multicenter Neuroimaging Platform
10 Université Paris-Saclay
11 CMRR - Centres Mémoire de Ressources et de Recherche Montpellier
12 CMRR - Centre Mémoire de Ressources et de Recherche Paris Nord Ile-de-France
13 Centre Mémoire [CHU de Toulouse]
14 Centre Hospitalier Emile Roux [AP-HP]
15 CMRR de Lorraine - Centres Mémoire de Ressources et de Recherche [CHRU Nancy]
16 Centre Mémoire de Ressources et de Recherche [CHU de Nantes]
17 Service de médecine interne [Mondor]
18 U955 Inserm - UPEC - IMRB - CEPIA/"Clinical Epidemiology And Ageing : Geriatrics, Primary Care and Public Health" [Créteil]
19 Centre Mémoire de Ressources et Recherche - CMRR [Haute-Normandie]
20 CHU Nîmes - Centre Hospitalier Universitaire de Nîmes
21 HLB - Hôpital Léopold Bellan
22 Centre Mémoire de Ressources et de Recherche [CHRU de Poitiers La Miletrie]
23 CMRR Nice - Centre Mémoire de Ressources et de Recherche [Nice]
24 Centre Mémoire de Ressources et de Recherche [CHU Amiens]
25 LNFP - Laboratoire de Neurosciences Fonctionnelles et Pathologies - UR UPJV 4559
26 CMRR Limoges - Centre de Mémoire de Ressources et de Recherches [Limoges]
27 Centre Mémoire de Ressources et de Recherche [CHRU de Tours Hôpital Bretonneau]
28 iBraiN - Imaging, Brain & Neuropsychiatry
29 CHU Pitié-Salpêtrière [AP-HP]
30 CMRR - Centre Mémoire de Ressources et de Recherche [CHRU de Besançon]
31 NEURO - Laboratoire de Neurosciences Intégratives et Cliniques - UFC (UR 481)
32 CMRR Reims - Champagne-Ardenne - Centre de Mémoire de Ressource et Recherche [Champagne-Ardenne-Reims]
33 VIEFRA - EA 3797 - Vieillissement, Fragilité
Luc Buee
Bruno Vellas
Joël Belmin

Résumé

INTRODUCTION:Diagnostic relevance of plasma amyloid β (Aβ) for Alzheimer's disease (AD) process yields conflicting results. The objective of the study was to assess plasma levels of Aβ42 and Aβ40 in amnestic mild cognitive impairment (MCI), nonamnestic MCI, and AD patients and to investigate relationships between peripheral and central biomarkers.METHODS:One thousand forty participants (417 amnestic MCI, 122 nonamnestic MCI, and 501 AD) from the Biomarker of AmyLoïd pepTide and AlZheimer's diseAse Risk multicenter prospective study with cognition, plasma, cerebrospinal fluid (CSF), and magnetic resonance imaging assessments were included.RESULTS:Plasma Aβ1-42 and Aβ1-40 were lower in AD (36.9 [11.7] and 263 [80] pg/mL) than in amnestic MCI (38.2 [11.9] and 269 [68] pg/mL) than in nonamnestic MCI (39.7 [10.5] and 272 [52] pg/mL), respectively (P = .01 for overall difference between groups for Aβ1-42 and P = .04 for Aβ1-40). Globally, plasma Aβ1-42 correlated with age, Mini-Mental State Examination, and APOE ε4 allele. Plasma Aβ1-42 correlated with all CSF biomarkers in MCI but only with CSF Aβ42 in AD.DISCUSSION:Plasma Aβ was associated with cognitive status and CSF biomarkers, suggesting the interest of plasma amyloid biomarkers for diagnosis purpose.Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.

Dates et versions

hal-02533144 , version 1 (06-04-2020)

Identifiants

Citer

Olivier Hanon, Jean-Sébastien Vidal, Sylvain Lehmann, Stéphanie Bombois, Bernadette Allinquant, et al.. Plasma amyloid levels within the Alzheimer's process and correlations with central biomarkers. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 2018, 14 (7), pp.858-868. ⟨10.1016/j.jalz.2018.01.004⟩. ⟨hal-02533144⟩
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