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Journal articles

Plasma amyloid levels within the Alzheimer's process and correlations with central biomarkers

Olivier Hanon 1, 2 Jean-Sébastien Vidal 1, 2 Sylvain Lehmann 3 Stéphanie Bombois 4 Bernadette Allinquant 5 Jean-Marc Tréluyer 6 Patrick Gelé 7 Christine Delmaire 4 Frédéric Blanc 8 Jean-François Mangin 9, 10 Luc Buee 7 Jacques Touchon 11 Jacques Hugon 12 Bruno Vellas 13 Evelyne Galbrun 14 Athanase Benetos 15 Gilles Berrut 16 Elena Paillaud 17 David Wallon 18 Giovanni Castelnovo 19 Lisette Volpe-Gillot 20 Marc Paccalin 21 Philippe-Henri Robert 22 Olivier Godefroy 23 Thierry Dantoine 24 Vincent Camus 25, 26 Joël Belmin 27 Pierre Vandel 28, 29 Jean-Luc Novella 30, 31 Emmanuelle Duron 1, 2 Anne-Sophie Rigaud 1, 2 Suzanna Schraen-Maschke 7 Audrey Gabelle 11
1 Centre de Mémoire de Ressources et de Recherche [Paris Broca]
2 EA 4468 - Maladie d'Alzheimer : marqueurs génétiques et vasculaires, neuropsychologies
3 Cellules Souches, Plasticité Cellulaire, Médecine Régénératrice et Immunothérapies (IRMB)
4 TCDV - Troubles cognitifs dégénératifs et vasculaires - U 1171
5 U894 / UMS 1266 - Institut de psychiatrie et neurosciences
6 CHU Necker - Enfants Malades [AP-HP]
7 LilNCog - Lille Neurosciences & Cognition - U 1172
8 Centre Mémoire de Ressources et de Recherche [Hôpitaux Civils de Colmar, Strasbourg]
9 CATI - CATI Multicenter Neuroimaging Platform
10 Université Paris-Saclay
11 CMRR - Centres Mémoire de Ressources et de Recherche Montpellier
12 CMRR - Centre Mémoire de Ressources et de Recherche Paris Nord Ile-de-France
13 Centre Mémoire de Ressources et de Recherche [CHU de Toulouse, Hôpital Purpan]
14 Centre Hospitalier Emile Roux [AP-HP]
15 CMRR de Lorraine - Centres Mémoire de Ressources et de Recherche [CHRU Nancy]
16 Centre Mémoire de Ressources et de Recherche [CHU de Nantes]
17 Service de médecine interne [Mondor]
18 Centre Mémoire de Ressources et Recherche - CMRR [Haute-Normandie]
19 CHU Nîmes - Centre Hospitalier Universitaire de Nîmes
20 Hôpital Léopold-Bellan
21 Centre Mémoire de Ressources et de Recherche [CHRU de Poitiers La Miletrie]
22 CMRR Nice - Centre Mémoire de Ressources et de Recherche [Nice]
23 Centre Mémoire de Ressources et de Recherche [CHU Amiens]
24 CMRR Limoges - Centre de Mémoire de Ressources et de Recherches [Limoges]
25 Centre Mémoire de Ressources et de Recherche [CHRU de Tours Hôpital Bretonneau]
26 iBrain - Inserm U1253 - UNIV Tours - Imagerie et cerveau
27 Service de Médecine Gériatrique [CHU Pitié-Salpêtrière]
28 CMRR - Centre Mémoire de Ressources et de Recherche [CHRU de Besançon]
29 NEURO - Laboratoire de Neurosciences Intégratives et Cliniques - UFC (UR 481)
30 CMRR Reims - Champagne-Ardenne - Centre de Mémoire de Ressource et Recherche [Champagne-Ardenne-Reims]
31 VIEFRA - EA 3797 - Vieillissement, Fragilité
Abstract : INTRODUCTION:Diagnostic relevance of plasma amyloid β (Aβ) for Alzheimer's disease (AD) process yields conflicting results. The objective of the study was to assess plasma levels of Aβ42 and Aβ40 in amnestic mild cognitive impairment (MCI), nonamnestic MCI, and AD patients and to investigate relationships between peripheral and central biomarkers.METHODS:One thousand forty participants (417 amnestic MCI, 122 nonamnestic MCI, and 501 AD) from the Biomarker of AmyLoïd pepTide and AlZheimer's diseAse Risk multicenter prospective study with cognition, plasma, cerebrospinal fluid (CSF), and magnetic resonance imaging assessments were included.RESULTS:Plasma Aβ1-42 and Aβ1-40 were lower in AD (36.9 [11.7] and 263 [80] pg/mL) than in amnestic MCI (38.2 [11.9] and 269 [68] pg/mL) than in nonamnestic MCI (39.7 [10.5] and 272 [52] pg/mL), respectively (P = .01 for overall difference between groups for Aβ1-42 and P = .04 for Aβ1-40). Globally, plasma Aβ1-42 correlated with age, Mini-Mental State Examination, and APOE ε4 allele. Plasma Aβ1-42 correlated with all CSF biomarkers in MCI but only with CSF Aβ42 in AD.DISCUSSION:Plasma Aβ was associated with cognitive status and CSF biomarkers, suggesting the interest of plasma amyloid biomarkers for diagnosis purpose.Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.
Keywords : Plasma biomarkers Mild cognitive impairment Alzheimer's disease Amyloid β peptides CSF biomarkers Cohort study Dementia Plasma biomarkers
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https://hal.univ-lorraine.fr/hal-02533144
Contributor : Philippe de Carvalho Connect in order to contact the contributor
Submitted on : Monday, April 6, 2020 - 11:37:27 AM
Last modification on : Friday, May 20, 2022 - 11:06:10 AM

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UNIV-LORRAINE | IMPACT-GEENAGE | UPEC-UPEM | UPEC | COMUE-NORMANDIE | UNIV-MONTPELLIER | UNIV-COTEDAZUR | UNIV-LILLE | SORBONNE-UNIVERSITE | BS | UNIV-PARIS5 | USPC | UNIV-PARIS | UP-SANTE | INSERM | SU-TI | UNIV-FCOMTE | URCA | VIEFRA | UNIV-TOURS | SU-MEDECINE | U-PICARDIE | LNFP

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Olivier Hanon, Jean-Sébastien Vidal, Sylvain Lehmann, Stéphanie Bombois, Bernadette Allinquant, et al.. Plasma amyloid levels within the Alzheimer's process and correlations with central biomarkers. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, Wiley, 2018, 14 (7), pp.858-868. ⟨10.1016/j.jalz.2018.01.004⟩. ⟨hal-02533144⟩

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