New Dual Small Molecules for Alzheimer’s Disease Therapy Combining Histamine H 3 Receptor (H3R) Antagonism and Calcium Channels Blockade with Additional Cholinesterase Inhibition

Rim Malek , Raquel Arribas , Alejandra Palomino-Antolin , Perle Totoson , Celine Demougeot , Tereza Kobrlova , Ondrej Soukup , Isabel Iriepa , Ignacio Moraleda , Daniel Diez-Iriepa , Justyna Godyń , Dawid Panek , Barbara Malawska , Monika Głuch-Lutwin , Barbara Mordyl , Agata Siwek , Fakher Chabchoub , José Marco-Contelles , Katarzyna Kiec-Kononowicz , Javier Egea , Cristóbal de Los Ríos , Lhassane Ismaili (1)

1 Laboratoires de neurosciences intégratives et cliniques (EA 481)

Domains: Chemical Sciences; Organic chemistry; Chemical Sciences; Medicinal Chemistry

Rim Malek, Raquel Arribas, Alejandra Palomino-Antolin, Perle Totoson, Celine Demougeot, et al.. New Dual Small Molecules for Alzheimer’s Disease Therapy Combining Histamine H 3 Receptor (H3R) Antagonism and Calcium Channels Blockade with Additional Cholinesterase Inhibition. Journal of Medicinal Chemistry, 2019, 62 (24), pp.11416-11422. ⟨10.1021/acs.jmedchem.9b00937⟩. ⟨hal-03654642⟩