What is the clinical impact of cerebrospinal fluid biomarkers on final diagnosis and management in patients with mild cognitive impairment in clinical practice? Results from a nation-wide prospective survey in France - Archive ouverte HAL Access content directly
Journal Articles BMJ Open Year : 2019

What is the clinical impact of cerebrospinal fluid biomarkers on final diagnosis and management in patients with mild cognitive impairment in clinical practice? Results from a nation-wide prospective survey in France

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Emmanuel Cognat
François Mouton Liger
  • Function : Author
Anne-Cécile Troussière
  • Function : Author
David Wallon
  • Function : Author
Julien Dumurgier
Eloi Magnin
Emmanuelle Duron
  • Function : Author
Audrey Gabelle
Bernard Croisile
  • Function : Author
Vincent de La Sayette
  • Function : Author
Alain Jager
  • Function : Author
Frederic Blanc
  • Function : Author
Elodie Bouaziz-Amar
  • Function : Author
Carole Miguet-Alfonsi
  • Function : Author
Muriel Quillard
  • Function : Author
Susanna Schraen
  • Function : Author
Nathalie Philippi
  • Function : Author
Emilie Beaufils
  • Function : Author
Florence Pasquier
  • Function : Author
Didier Hannequin
  • Function : Author
Philippe Robert
Jacques Hugon
  • Function : Author
Claire Paquet
  • Function : Author

Abstract

Objectives New diagnostic criteria for Alzheimer’s disease (AD) include cerebrospinal fluid (CSF) biomarkers that allow diagnosis at the stage of mild cognitive impairment (MCI). However, the impact of CSF biomarkers in MCI populations in clinical practice has been poorly evaluated. The objective of this study is to assess the use and impact in clinical practice of AD CSF biomarkers in French memory clinics. Design We performed a nation-wide, prospective survey between March 2012 and September 2014. Data over the same period was extracted from the French National Database (Banque Nationale Alzheimer, BNA) and compared with the results of the survey. Setting 29 secondary and tertiary memory clinics in France. Participants Clinicians prescribing lumbar puncture (LP) in order to measure AD CSF biomarkers. Clinicians completed a two-part questionnaire for each of their patients undergoing LP. Primary and secondary outcome measures Assessment of diagnosis, level of confidence before and after CSF biomarkers and impact on management in patients who underwent LP for CSF AD biomarkers in clinical routine. Results 977 questionnaires were completed, of which 61 were excluded because of unknown initial/final diagnosis or non-contributory CSF results. Of 916 patients reported, 153 (16.7%) had MCI as the initial diagnosis, of which 51 (33.3%) displayed an AD profile. CSF biomarkers resulted in a change in diagnosis in 44 patients (28.8%). Confidence level significantly increased after LP (8.3±1.4vs 6.73±1.18, p<0.0001), and CSF results modified management in 71/156 patients (46.4%), including 36 (23.5%) enrolled in clinical trials. Comparison of change in diagnosis with the BNA population revealed no difference (32.24%, p=0.4). Conclusion This nation-wide survey, reflecting clinical practice in French memory clinics, describes the impact of CSF AD biomarkers in patients with MCI in clinical practice.

Dates and versions

hal-03630155 , version 1 (04-04-2022)

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Emmanuel Cognat, François Mouton Liger, Anne-Cécile Troussière, David Wallon, Julien Dumurgier, et al.. What is the clinical impact of cerebrospinal fluid biomarkers on final diagnosis and management in patients with mild cognitive impairment in clinical practice? Results from a nation-wide prospective survey in France. BMJ Open, 2019, 9 (5), pp.e026380. ⟨10.1136/bmjopen-2018-026380⟩. ⟨hal-03630155⟩

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