Cerebrospinal Fluid Levels of Kininogen‐1 Indicate Early Cognitive Impairment in Parkinson's Disease

Ioanna Markaki , Sofia Bergström , Panagiota Tsitsi , Julia Remnestål , Anna Månberg , Ellen Hertz , Wojciech Paslawski , Kimmo Sorjonen , Mathias Uhlén , Graziella Mangone , Stephanie Carvalho , Olivier Rascol , Wassilios Meissner , Eloi Magnin (1) , Ullrich Wüllner , Jean-Christophe Corvol , Peter Nilsson , Per Svenningsson , Jean‐christophe Corvol

1 UFC - Université de Franche-Comté

The aim of this study was to investigate CSF markers associated with cognition in early PD.

Cognitive impairment is common in patients with PD. Core markers of Alzheimer's dementia have been related also to PD dementia, but no disease-specific signature to predict PD dementia exists to date.

Keywords: Parkinson's disease; cognition; kininogen-1; neurodegeneration

Domains: Life Sciences [q-bio]

Ioanna Markaki, Sofia Bergström, Panagiota Tsitsi, Julia Remnestål, Anna Månberg, et al.. Cerebrospinal Fluid Levels of Kininogen‐1 Indicate Early Cognitive Impairment in Parkinson's Disease. Movement Disorders, 2020, 35 (11), pp.2101-2106. ⟨10.1002/mds.28192⟩. ⟨hal-03630128⟩