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Journal articles
Association of Amyotrophic Lateral Sclerosis and Alzheimer’s Disease: New Entity or Coincidence? A Case Series
Abstract : Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia have a strong clinical, genetic, and pathological connection but association of ALS with Alzheimer’s disease (AD) is seldom reported. We report a series of 5 cases of AD associated with ALS. Our patients presented with cognitive deterioration with episodic memory impairment meeting criteria for AD. ALS occurred subsequently in all cases and its phenotype was not homogenous. Amyloid process was confirmed in four cases with cerebrospinal fluid biomarkers. One case underwent postmortem exam, demonstrating hallmarks lesions of both diseases. This series highlights that ALS-AD phenotype could be a specific underexplored entity.
https://hal-univ-fcomte.archives-ouvertes.fr/hal-03630021
Contributor : Eloi Magnin Connect in order to contact the contributor
Submitted on : Monday, April 4, 2022 - 4:59:41 PM
Last modification on : Monday, April 4, 2022 - 4:59:41 PM
Contributor : Eloi Magnin Connect in order to contact the contributor
Submitted on : Monday, April 4, 2022 - 4:59:41 PM
Last modification on : Monday, April 4, 2022 - 4:59:41 PM