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Indications and results of liver transplantation for Echinococcus alveolar infection: an overview

Abstract : Alveolar echinococcosis (AE) of the liver, caused by the larval stage of the fox tapeworm Echinococcus multilocularis, has the characteristics of a slow-growing liver cancer. It is one of the rare parasitic diseases for which a parasitolytic drug is not yet available, and AE is lethal in the absence of appropriate therapeutic management. Complete surgical resection of the parasite at an early stage of infection provides favourable prospects for cure, but, due to a long clinical latency, many cases are diagnosed at an advanced stage, so that partial liver resection can be performed in only 35% of patients. Benzimidazole (BZM) treatment is given in inoperable cases but these compounds are only parasitostatic, and lifelong therapy is required. During the past 20 years some centres have considered liver transplantation (LT) for the treatment of incurable AE.
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Submitted on : Thursday, January 20, 2022 - 11:39:25 AM
Last modification on : Friday, January 21, 2022 - 3:08:01 AM

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Solange Bresson-Hadni, Stéphane Koch, Jean-Philippe Miguet, Michel Gillet, Georges-André Mantion, et al.. Indications and results of liver transplantation for Echinococcus alveolar infection: an overview. Langenbeck's Archives of Surgery, Springer Verlag, 2003, 388 (4), pp.231-238. ⟨10.1007/s00423-003-0394-2⟩. ⟨hal-03537140⟩

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