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Circulating concentrations of interleukin-18, interleukin-18 binding protein, and gamma interferon in patients with alcoholic hepatitis

Abstract : Alcoholic hepatitis (AH) is associated with dysregulated inflammatory and immune responses. interleukin-18 (IL-18), described as gamma interferon (gammaIFN)-inducible factor, and its natural antagonist, IL-18 binding protein (IL-18 BP), has not been fully studied in patients with AH. Thus, our aim was: (i) to determine plasma values of IL-18, IL-18 BP, gammaIFN, and tumor necrosis factor alpha (TNF)-alpha in patients hospitalized for biopsy-proven AH; (ii) to correlate these cytokines with the severity of AH, as assessed by Maddrey's discriminant function (DF), the degree of liver failure using the Child-Pugh score and blood neutrophils; (iii) to compare cytokines values in survivors and non-survivors.
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Submitted on : Thursday, January 20, 2022 - 11:36:57 AM
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Laurent Spahr, Irene Garcia, Solange Bresson-Hadni, Laura Rubbia-Brandt, Reto Guler, et al.. Circulating concentrations of interleukin-18, interleukin-18 binding protein, and gamma interferon in patients with alcoholic hepatitis. Liver International, Wiley-Blackwell, 2004, 24 (6), pp.582-587. ⟨10.1111/j.1478-3231.2004.0967.x⟩. ⟨hal-03537137⟩

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