Soluble TNF-R1, but not tumor necrosis factor alpha, predicts the 3-month mortality in patients with alcoholic hepatitis

Laurent Spahr , Emile Giostra , Jean-Louis Frossard , Solange Bresson-Hadni (1) , Laura Rubbia-Brandt , Antoine Hadengue

1 Service d'Hépatologie [CHRU Besançon]

In alcoholic hepatitis (AH), soluble TNF alpha receptor-1 (sTNF-R1) is increased. Elevated TNF alpha predicts mortality, but infection influences TNF alpha values. In patients with AH, we determined the prognostic value of TNF alpha, sTNF-R1, and lipopolysaccharide binding protein (LBP) and CD14, both involved in endotoxemia-associated inflammation.

Domaines: Santé

Laurent Spahr, Emile Giostra, Jean-Louis Frossard, Solange Bresson-Hadni, Laura Rubbia-Brandt, et al.. Soluble TNF-R1, but not tumor necrosis factor alpha, predicts the 3-month mortality in patients with alcoholic hepatitis. Journal of Hepatology, 2004, 41 (2), pp.229-234. ⟨10.1016/j.jhep.2004.04.028⟩. ⟨hal-03537119⟩