Soluble TNF-R1, but not tumor necrosis factor alpha, predicts the 3-month mortality in patients with alcoholic hepatitis - Archive ouverte HAL Access content directly
Journal Articles Journal of Hepatology Year : 2004

Soluble TNF-R1, but not tumor necrosis factor alpha, predicts the 3-month mortality in patients with alcoholic hepatitis

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Laurent Spahr
  • Function : Author
Emile Giostra
  • Function : Author
Jean-Louis Frossard
  • Function : Author
Laura Rubbia-Brandt
  • Function : Author
Antoine Hadengue
  • Function : Author

Abstract

In alcoholic hepatitis (AH), soluble TNF alpha receptor-1 (sTNF-R1) is increased. Elevated TNF alpha predicts mortality, but infection influences TNF alpha values. In patients with AH, we determined the prognostic value of TNF alpha, sTNF-R1, and lipopolysaccharide binding protein (LBP) and CD14, both involved in endotoxemia-associated inflammation.

Dates and versions

hal-03537119 , version 1 (20-01-2022)

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Laurent Spahr, Emile Giostra, Jean-Louis Frossard, Solange Bresson-Hadni, Laura Rubbia-Brandt, et al.. Soluble TNF-R1, but not tumor necrosis factor alpha, predicts the 3-month mortality in patients with alcoholic hepatitis. Journal of Hepatology, 2004, 41 (2), pp.229-234. ⟨10.1016/j.jhep.2004.04.028⟩. ⟨hal-03537119⟩

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