Effects of a short-course of amoxicillin/clavulanic acid on systemic and mucosal immunity in healthy adult humans - Archive ouverte HAL Access content directly
Journal Articles International Immunopharmacology Year : 2005

Effects of a short-course of amoxicillin/clavulanic acid on systemic and mucosal immunity in healthy adult humans

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Vinciane Dufour
  • Function : Author
Jean-François Faucher
  • Function : Author
Emmanuel Bard
  • Function : Author
Eric Robinet
  • Function : Author
  • PersonId : 762360
  • IdRef : 07470799X
Renaud Piarroux
  • Function : Author
Dominique-Angèle Vuitton
  • Function : Author
Dominique Meillet
  • Function : Author

Abstract

Although amoxicillin/clavulanic acid (AMC) is the most frequently administered antibiotic in France, its in vivo effects on immunity in healthy adults have never, to our knowledge, been described. Eighteen healthy adult male volunteers, 25+/-6 years old, were treated for 5 days with oral amoxicillin (1 g) /clavulanate potassium (125 mg), two times daily. Systemic and local intestinal immunity parameters were sequentially explored before, during and after the antibiotic treatment. No significant differences were obtained for transudation markers (albumin and alpha1-antitrypsin) in sera, feces and saliva, showing that AMC did not induce inflammatory reaction. Phagocytosis, peripheral blood cell subsets, intracellular interferon (IFN)-gamma and tumor necrosis factor (TNF)-alpha production by natural killer (NK) cells and cytotoxic T lymphocytes, intracellular TNF-alpha production by monocytes showed no significant differences throughout the trial. In fecal outputs, no significant differences were found in secretory immunoglobulin A (S-IgA), lactoferrin (Lf), lysozyme (Lz) and transforming growth factor (TGF)-beta1. In sera, concentrations of total IgA (T-IgA), S-IgA, IgM, Lf and Lz did not show any significant variations throughout the study, whereas concentrations of IgG were slightly but significantly reduced 15 days after AMC treatment. In saliva, concentrations of T-IgA were slightly but significantly higher, whereas S-IgA concentrations were unchanged. Our results showed that oral AMC intake did not induce any significant adverse effects on immunity in adult humans.

Dates and versions

hal-03534537 , version 1 (19-01-2022)

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Vinciane Dufour, Laurence Millon, Jean-François Faucher, Emmanuel Bard, Eric Robinet, et al.. Effects of a short-course of amoxicillin/clavulanic acid on systemic and mucosal immunity in healthy adult humans. International Immunopharmacology, 2005, 5 (5), pp.917-928. ⟨10.1016/j.intimp.2005.01.007⟩. ⟨hal-03534537⟩
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