Characterization of OXA-204, a Carbapenem-Hydrolyzing Class D β-Lactamase from Klebsiella pneumoniae - Archive ouverte HAL Access content directly
Journal Articles Antimicrobial Agents and Chemotherapy Year : 2012

Characterization of OXA-204, a Carbapenem-Hydrolyzing Class D β-Lactamase from Klebsiella pneumoniae

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Abstract

ABSTRACT A Klebsiella pneumoniae clinical isolate recovered in Tunisia showed resistance to all β-lactams and decreased susceptibility to carbapenems. K. pneumoniae 204 expressed the carbapenem-hydrolyzing β-lactamase OXA-204, differing from OXA-48 by two amino acid substitutions (Gln98His and Thr99Arg) (class D β-lactamase [DBL] numbering). OXA-48 and OXA-204 shared similar resistance profiles, hydrolyzing carbapenems but sparing broad-spectrum cephalosporins. The bla OXA-204 gene was located on a ca. 150-kb IncA/C-type plasmid, which also carried the bla CMY-4 gene. The bla OXA-204 gene was associated with an IS Ecp1 element, whereas the bla OXA-48 genes are usually associated with IS 1999 .

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hal-03505794 , version 1 (31-12-2021)

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Anaïs Potron, Patrice Nordmann, Laurent Poirel. Characterization of OXA-204, a Carbapenem-Hydrolyzing Class D β-Lactamase from Klebsiella pneumoniae. Antimicrobial Agents and Chemotherapy, 2012, 57 (1), pp.633-636. ⟨10.1128/AAC.01034-12⟩. ⟨hal-03505794⟩
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