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Derepressed Transfer Properties Leading to the Efficient Spread of the Plasmid Encoding Carbapenemase OXA-48

Abstract : ABSTRACT The current emergence of the carbapenemase OXA-48 among Enterobacteriaceae is related to the spread of a single IncL/M-type plasmid, pOXA-48a. This plasmid harbors the bla OXA-48 gene within a composite transposon, Tn 1999 , which is inserted into the tir gene, encoding a transfer inhibition protein. We showed that the insertion of Tn 1999 into the tir gene was involved in a higher transfer frequency of plasmid pOXA-48a. This may likely be the key factor for the successful dissemination of this plasmid.
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https://hal-univ-fcomte.archives-ouvertes.fr/hal-03505788
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Submitted on : Friday, December 31, 2021 - 4:43:45 PM
Last modification on : Saturday, January 1, 2022 - 3:00:18 AM

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Anaïs Potron, Laurent Poirel, Patrice Nordmann. Derepressed Transfer Properties Leading to the Efficient Spread of the Plasmid Encoding Carbapenemase OXA-48. Antimicrobial Agents and Chemotherapy, American Society for Microbiology, 2013, 58 (1), pp.467-471. ⟨10.1128/AAC.01344-13⟩. ⟨hal-03505788⟩

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