Rapid detection of colistin resistance in Acinetobacter baumannii using MALDI-TOF-based lipidomics on intact bacteria

Anaïs Potron (1, 2) , Patrick Plésiat (1, 2) , Thierry Naas (3) , Laurent Dortet (4, 3, 5) , Rémy A. Bonnin (3) , Alain Filloux (4) , Gérald Larrouy-Maumus (4)

1 CNR - Centre National de Référence de la Résistance aux Antibiotiques
2 Service de bactériologie [Besançon]
3 AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre)
4 MRC CMBI - Medical Research Council Centre for Molecular Bacteriology and Infection [Londres, Royaume-Uni]
5 Faculté de Médecine Paris Sud, Le Kremlin-Bicêtre

Nineteen Proteus mirabilis isolates producing the carbapenemase OXA-23 were recovered over a 2-year period in 19 French hospitalized patients, of whom 12 had community onset infections. The isolates exhibited a slightly reduced susceptibility to carbapenems.

Domains: Life Sciences [q-bio]; Microbiology and Parasitology

Anaïs Potron, Patrick Plésiat, Thierry Naas, Laurent Dortet, Rémy A. Bonnin, et al.. Rapid detection of colistin resistance in Acinetobacter baumannii using MALDI-TOF-based lipidomics on intact bacteria. Scientific Reports, 2018, 8 (1), pp.669-673. ⟨10.1038/s41598-018-35041-y⟩. ⟨hal-03505776⟩