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Journal articles

High prevalence of OXA-23 carbapenemase-producing Proteus mirabilis among amoxicillin-clavulanate resistant isolates in France

Amélie Lombes 1, 2 Rémy A. Bonnin 3, 4, 2 Frédéric Laurent 5 Hélène Guet-Revillet 6 Emmanuelle Bille 7, 8 Vincent Cattoir 9, 10 Marie-Sarah Fangous 11 Cécile Le Brun 12, 13 Vincent Fihman 14 Frédéric Janvier 15 Marie-Pierre Otto 15 Anaïs Potron 16, 4, 2 Stéphane Corvec 17, 18 Louise Ruffier d'Epenoux 18, 17 Assaf Mizrahi 19, 20 Laurent Dortet 1, 21, 2, * 
* Corresponding author
1 AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre)
2 IMVA-HB - Immunologie des maladies virales, auto-immunes, hématologiques et bactériennes
3 Team Resist [Le Kremlin-Bicêtre]
IMVA-HB - Immunologie des maladies virales, auto-immunes, hématologiques et bactériennes
4 CNR - Centre National de Référence de la Résistance aux Antibiotiques
5 IAI - Institut des Agents Infectieux [Lyon]
6 Institut Fédératif de Biologie (IFB) - Hôpital Purpan
7 AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP)
8 Laboratoire de Microbiologie Clinique [AP-HP Hôpital Necker-Enfants Malades]
9 Laboratoire de Bactériologie et Hygiène Hospitalière [Rennes]
10 BRM - ARN régulateurs bactériens et médecine
11 CHIC - Centre Hospitalier Intercommunal de Cornouaille
12 CHRU Tours - Centre Hospitalier Régional Universitaire de Tours
13 Hôpital Bretonneau
14 CHU Henri Mondor
15 HIA - Hopital d'instruction des armées Sainte-Anne [Toulon]
16 Service de bactériologie [Besançon]
17 CHU Nantes - Centre hospitalier universitaire de Nantes
18 CRCINA - Centre de Recherche en Cancérologie et Immunologie Nantes-Angers
19 Centre hospitalier Saint-Joseph [Paris]
20 MICALIS - MICrobiologie de l'ALImentation au Service de la Santé
21 CNR - Centre National de Référence de la Résistance aux Antibiotiques [CHU Rennes]
Abstract : In this multicentric study performed in 12 French hospitals, we reported that 26.9% (14/52) of the amoxicillin/clavulanate-resistant Proteus mirabilis isolates produced the OXA-23 carbapenemase. We found that inhibition zone diameter less than 11 mm around amoxicillin/clavulanate disc was an accurate screening cut-off to detect these OXA-23 producers. We confirmed by whole genome sequencing that these OXA-23-producers all belonged to the same lineage that has been demonstrated to disseminate OXA-23 or OXA-58 in P. mirabilis .
Keywords : Acinetobacter OXA-23 Proteae carbapenemase epidemiology infectious clones.
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Journal articles
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https://hal-univ-fcomte.archives-ouvertes.fr/hal-03505721
Contributor : Isabelle HOSTALIER Connect in order to contact the contributor
Submitted on : Wednesday, April 13, 2022 - 10:52:53 AM
Last modification on : Thursday, April 14, 2022 - 10:20:59 AM

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INSERM | CEA | UNIV-NANTES | AGROPARISTECH | HCL | UNIV-RENNES1 | CNRS | UNIV-FCOMTE | UNIV-ANGERS | U835 | CEA-UPSAY | UR1-UFR-SVE | UNIV-PARIS-SACLAY | CRCINA | UNIV-RENNES | INRAE | UR1-BIO-SA | GS-BIOSPHERA | GS-LIFE-SCIENCES-HEALTH | GS-HEALTH-DRUG-SCIENCES | MICA-UNITES | MICALIS

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Amélie Lombes, Rémy A. Bonnin, Frédéric Laurent, Hélène Guet-Revillet, Emmanuelle Bille, et al.. High prevalence of OXA-23 carbapenemase-producing Proteus mirabilis among amoxicillin-clavulanate resistant isolates in France. Antimicrobial Agents and Chemotherapy, American Society for Microbiology, 2022, 66 (2), pp.e0198321. ⟨10.1128/AAC.01983-21⟩. ⟨hal-03505721⟩

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