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High prevalence of OXA-23 carbapenemase-producing Proteus mirabilis among amoxicillin-clavulanate resistant isolates in France

Amélie Lombes 1, 2 Rémy A. Bonnin 3, 4, 2 Frédéric Laurent 5 Hélène Guet-Revillet 6 Emmanuelle Bille 7, 8 Vincent Cattoir 9, 10 Marie-Sarah Fangous 11 Cécile Le Brun 12, 13 Vincent Fihman 14 Frédéric Janvier 15 Marie-Pierre Otto 15 Anaïs Potron 16, 4, 2 Stéphane Corvec 17, 18 Louise Ruffier d'Epenoux 18, 17 Assaf Mizrahi 19, 20 Laurent Dortet 1, 21, 2, * 
Abstract : In this multicentric study performed in 12 French hospitals, we reported that 26.9% (14/52) of the amoxicillin/clavulanate-resistant Proteus mirabilis isolates produced the OXA-23 carbapenemase. We found that inhibition zone diameter less than 11 mm around amoxicillin/clavulanate disc was an accurate screening cut-off to detect these OXA-23 producers. We confirmed by whole genome sequencing that these OXA-23-producers all belonged to the same lineage that has been demonstrated to disseminate OXA-23 or OXA-58 in P. mirabilis .
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https://hal-univ-fcomte.archives-ouvertes.fr/hal-03505721
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Submitted on : Wednesday, April 13, 2022 - 10:52:53 AM
Last modification on : Thursday, April 14, 2022 - 10:20:59 AM

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Amélie Lombes, Rémy A. Bonnin, Frédéric Laurent, Hélène Guet-Revillet, Emmanuelle Bille, et al.. High prevalence of OXA-23 carbapenemase-producing Proteus mirabilis among amoxicillin-clavulanate resistant isolates in France. Antimicrobial Agents and Chemotherapy, American Society for Microbiology, 2022, 66 (2), pp.e0198321. ⟨10.1128/AAC.01983-21⟩. ⟨hal-03505721⟩

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