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Acquisition of Class C β-Lactamase PAC-1 by Sequence Type 644 Strains of Pseudomonas aeruginosa

Abstract : Four sequence type 664 (ST664) (serotype O:5) strains of Pseudomonas aeruginosa that were highly resistant to antibiotics, including ceftolozane-tazobactam and ceftazidime-avibactam, but were susceptible to colistin were found to harbor the gene encoding the rare class C β-lactamase PAC-1 on a chromosomally located Tn 1721 -like transposon. The bla PAC-1 gene was associated with the 16S rRNA methylase determinant rmtF2 , which confers pan-aminoglycoside resistance.
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https://hal-univ-fcomte.archives-ouvertes.fr/hal-03483124
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Submitted on : Thursday, December 16, 2021 - 12:11:21 PM
Last modification on : Thursday, January 13, 2022 - 11:58:09 AM

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Maxime Bour, Damien Fournier, Thomas Jové, Armelle Pouzol, Guillaume Miltgen, et al.. Acquisition of Class C β-Lactamase PAC-1 by Sequence Type 644 Strains of Pseudomonas aeruginosa. Antimicrobial Agents and Chemotherapy, American Society for Microbiology, 2019, 63 (12), ⟨10.1128/AAC.01375-19⟩. ⟨hal-03483124⟩

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