Acquisition of Class C β-Lactamase PAC-1 by Sequence Type 644 Strains of Pseudomonas aeruginosa

Maxime Bour (1) , Damien Fournier (1) , Thomas Jové , Armelle Pouzol , Guillaume Miltgen , Frédéric Janvier , Katy Jeannot (1, 2) , Patrick Plésiat (1, 2)

1 CNR - Centre National de Référence de la Résistance aux Antibiotiques
2 LCE - Laboratoire Chrono-environnement (UMR 6249)

Four sequence type 664 (ST664) (serotype O:5) strains of Pseudomonas aeruginosa that were highly resistant to antibiotics, including ceftolozane-tazobactam and ceftazidime-avibactam, but were susceptible to colistin were found to harbor the gene encoding the rare class C β-lactamase PAC-1 on a chromosomally located Tn 1721 -like transposon. The bla PAC-1 gene was associated with the 16S rRNA methylase determinant rmtF2 , which confers pan-aminoglycoside resistance.

Domains: Life Sciences [q-bio]; Microbiology and Parasitology

Maxime Bour, Damien Fournier, Thomas Jové, Armelle Pouzol, Guillaume Miltgen, et al.. Acquisition of Class C β-Lactamase PAC-1 by Sequence Type 644 Strains of Pseudomonas aeruginosa. Antimicrobial Agents and Chemotherapy, 2019, 63 (12), ⟨10.1128/AAC.01375-19⟩. ⟨hal-03483124⟩